Synthesis of modified pyridine and bipyridine substituted coumarins as potent antimicrobial agents

Synthesis of modified pyridine and bipyridine substituted coumarins as potent antimicrobial agents

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In search for new antimicrobial agents a series of new modified pyridine and bipyridine substituted coumarins 5a-y was designed and synthesized by adopting molecular hybridization strategy.All the synthesized compounds valhalla axys were evaluated for their in vitro antimicrobial activity using broth dilution method against selected bacterial (Gram-positive and Gram-negative) and fungal strains.Compounds 5a, 5f, 5g, 5n, 5r, 5t, 5w, 5x and 5y demonstrated promising antibacterial activity while other derivatives showed comparable activity to standard iphone 14 price texas drugs used as reference.